12(R)-HETE | CAS 82337-46-0 | Chemical-Suppliers

Element: hete

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C-S » Chemicals » hete-PX82284

Identification

12(R)-HETE

CAS:

82337-46-0

EINECS:

Molecular Formula:

C₂₀H₃₂ O₃

MDL:

SMILES:

CCCCC/C=CC[C@H](/C=C/C=CC/C=CCCCC(=O)O)O

Synonym:

5,8,10,14-Eicosatetraenoicacid, 12-hydroxy-, [R-(E,Z,Z,Z)]- ; 12(R)-5,8,10,14-Hydroxyeicosatetraenoicacid ; 12(R)-HETE ; 12(R)-Hydroxy-5(Z),8(Z),10(E),14(Z)-eicosatetraenoic acid ; 12-HETE ; 5,8,10,14-Eicosatetraenoicacid, 12-hydroxy-, (5Z,8Z,10E,12R,14Z)-

Description

12(R)-HETE is an arachidonic acid metabolite synthesized in the 12-lipoxygenase pathway in platelets and macrophages. Studies suggest that 12(R)-HETE is a better stimulator of leukocyte aggregation and enhances leukocyte chemokinesis better than its enantiomer 12(S)-HETE. In addition, 12(R)-HETE is an inhibitor of the Na⁺/K⁺ ATPase pump in corneal epithelium which could possibly have a role in regulating ocular transparency and aqueous human secretion.