5(S)-HETE | CAS 70608-72-9 | Chemical-Suppliers

Element: hete

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C-S » Chemicals » hete-PX78301

Identification

5(S)-HETE

CAS:

70608-72-9

EINECS:

Molecular Formula:

C₂₀H₃₂ O₃

MDL:

MFCD00065820

SMILES:

CCCCC/C=CC/C=CC/C=CC=C[C@H](CCCC(=O)O)O

Synonym:

5-hydroxy-6,8,11,14-eicosatetraenoicacid ; 5(s)-hete lipid maps ms standard ; 5-hete ; 5(s)-hete ; 5-hydroxyeicosatetraenoic acid ; 5-hydroxyeicosatetraenoicacid ; (5s,6e,8z,11z,14z)-5-hydroxy-6,8,11,14-eicosatetraenoicacid ; 5(s)-hydroxyeicosatetraenoic acid ; 6,8,11,14-eicosatetraenoicacid, 5-hydroxy-, (5s,6e,8z,11z,14z)- ; 5s-hydroxy-6,8,11,14-(e,z,z,z)-eicosatetraenoic acid ; 5(s)-hydroxy-6-trans-8,11,14-cis-eicosatetraenoic acid ; c04805 ; 5-l-hydroxy-6,8,11,14-eicosatetraenoicacid ; (+)-5-hete, 5(s)-hete ; 6,8,11,14-eicosatetraenoicacid, 5-hydroxy-, [s-(e,z,z,z)]- ; 5-hydroxyicosatetraenoic acid ; (+)-5-hete ; 5-hydroxyeicosatetraenoate

Description

5(S)-HETE is a product of the arachidonic acid metabolism lipoxygenase pathway. It is chemotactic and chemokinetic for human neutrophils, the most abundant white blood cells of the mammalian immune system. It has been shown to elevate cytosolic Ca²⁺, inducing protein kinase C mobilization and thus influencing neutrophil function. It has been observed to stimulate the release of lysozymes from polymorphonuclear leukocytes. It has also been observed to stimulate the release of beta-N-acetylglucosaminidase from polymorphonuclear leukocytes.

Suppliers

Santa Cruz Biotechnology, Inc.

200939

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Prices & Availability

Data is processed

Properties for 5(S)-HETE

Molecular Weight:

320.52 g·mol−1

Solubility:

Soluble in methanol, water, HOAc, NH4OH, DMSO (50 mg/ml), DMF (50 mg/ml), and PBS pH 7.2 (~1 mg/ml).

Safety & Transport Information

Mutation data reported. When heated to decomposition it emits acrid smoke and irritating vapors.

Risk Codes:

R11 - Highly flammable
R36/37/38 - Irritating to eyes, respiratory system and skin

Safety Codes:

S16 - Keep away from sources of ignition - No smoking
S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
S36 - Wear suitable protective clothing

Hazard Symbols:

F, Xi