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Triptolide

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Formula: C20H24O6
CAS: 38748-32-2
search Element: triptolide

Identification

Structural Formula
Triptolide
CAS:
38748-32-2
EINECS:
Molecular Formula:
C20H24O6
MDL:
MFCD00210565
SMILES:
CC(C)[C@@]12[C@@H](O1)[C@H]3[C@@]4(O3)[C@]5(CCC6=C(C5C[C@H]7[C@]4([C@@H]2O)O7)COC6=O)C
Synonym:
triptolide95% ; nsc 163062 ; triptonide(p) ; triptolide ; triptolide(p) ; triptolide(pg490) ; pg490 ; triptolid ; triptolide, >=98% ; triptolide tlc


Description

Triptolide is a diterpene triepoxide antibiotic originally isolated from extracts of the herb Tripterygium wilfordii Hook F (TWHF). Triptolide has been shown to induce apoptosis of T lymphocytes by activating caspases, displaying an increase of DEVD-cleavable caspase activity correlated with the apoptosis. The proliferation of rheumatoid synovial fibroblasts characteristic of rheumatoid arthritis was similarly suppressed by treatment with Triptolide through an increase in caspase-3 activity. Cytokine gene expression in blood lymphocytes and T-cells are also suppressed by Triptolide, blocking the transcriptional activation of purine-box/antigen receptor response element/nuclear factor of activated T-cells (NF-AT) and of NF-kappaB.


Suppliers

Autech Industry Co.,Limited
AIC2701080
Chengdu Pufeide Biotech. Co., Ltd
CPB3301320
Conscientia Industrial Co., Ltd (Zhejiang Conscientia Pharmaceutical)
CI6902760
Chemlyte Solutions
CS180540
Indofine Chemical Co, Inc.
06-1285
Evonik ( formerly Wilshire Technologies, Inc. )
E4801920
CSNpharm, Inc.
CSN19415
Finetech Industry Limited
FIL2501000
Pharmacore Co., Limited
PL230690
Acinopeptide Co., Ltd.
A220440
Simagchem Corporation
SC210630
Xingrui Industry Co., Limited
XIL2901160
Zehao Industry Co., Ltd.
ZI240720
BOC Sciences
BS120360
Leap Chem Co., Ltd
LC180540
Santa Cruz Biotechnology, Inc.
200122
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Prices & Availability




Data is processed


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Properties for Triptolide

Molecular Weight:
360.4 g·mol−1
Density:
1.48 g/cm3
Melting point:
226-227 °C
Boiling point:
601.7 °C at 760 mmHg
Solubility:
DMSO: soluble
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Safety & Transport Information

Safety Codes:
S22 - Do not breathe dust
S24/25 - Avoid contact with skin and eyes
Storage temperature :
2-8°C
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Alternative Distributors of [Triptolide]

Producers or manufacturers change the product range from time to time. The following companies
have appeared as suppliers in the past / currently not verified

Hallochem Pharma Co., Ltd. | 3B Scientific Corporation | Jinan Great Chemical Co., Ltd. | Longschem Co., Ltd. | Chengdu Biopurify Phytochemicals Ltd. | ShangHai Biochempartner Co., Ltd. | Shanghai Tauto Biotech Co., Ltd. | Chengdu Qiaofeng Technological Development Co., Ltd. | Shanghai Yingxuan Chempharm Co., Ltd. | Suzhou Rovathin Pharmatech Co., Ltd | Shanghai Brightol International Co., Ltd. | Lanospharma Laboratories Co., Ltd. | Shanghai Boyle Chemical Co., Ltd. | Baoji Herbest Bio-Tech Co., Ltd. | Bichem Lab Co., Ltd. | Cfm Oskar Tropitzsch GmbH | Shanghai DND Pharm-Technology Co.,Inc. | Chengdu Conut Intl. Co., Ltd. | BOC Sciences | Xiamen Hisunny Chemical Co., Ltd. | Clearsynth Canada INC.

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