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L-trans-Epoxysuccinyl-Leu-4-guanidinobutylamide

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Formula: C15H27N5O5
CAS: 66701-25-5

Identification

Structural Formula
L-trans-Epoxysuccinyl-Leu-4-guanidinobutylamide
CAS:
66701-25-5
EINECS:
Molecular Formula:
C15H27N5O5
MDL:
MFCD00080261
Synonym:
e64(proteinaseinhibitor) ; epoxysuccinyl-l-leucylamido-(4-guanidino)butane ; e-64 research grade ; e-64 protease inhibitor ; e-64 ; l-trans-epoxysuccinyl-leu-agmatine ; e-64, l-trans-epoxysuccinyl-leu-agmatine ; e-64 hemihydrate ; proteinaseinhibitore64 ; thiolproteaseinhibitor


Description

An irreversible, highly selective cysteine protease inhibitor. Shows no inhibition against serine proteases with an except of trypsin. Interacts with the Sn subsites of proteases. For in vivo studies the use of E-64 as a cysteine protease inhibitor is highly recommanded because it has a specific inhibition, it is permeable in cells and tissues and has low toxicity. Inhibits activation-induced programmed cell death and restores defective immune responses in HIV+ donors Potential targets: Papain, Bromelain, Ficin, Cathepsin B, H and L, Tumor-Cathepsin, Calpain References: K. Hanada, M. Tamai, M. Yamagishi, S.Ohmura, J. Sawada & I. Tanaka (1978) Isolation and Characterization of E-64, a New Thiol Protease Inhibitor. Agric. Bioi. Chem., 42 (3), 523-­528. A. J. Barrett, A. A. Kembhavi, M. A. Brown, H. Kirschke, C. G. Knight, M. Tamai, K. Hanada (1982) L-trans-Epoxysuccinyl-leucylamido(4-guanidino)butane (E-64) and its analogues as inhibitors of cysteine proteinases including cathepsins B, H and L. Biochem J., 201(1), 189­98. K. Matsumoto, K. Mizoue, K. Kitamura, W. C. Tse, C. P. Huber, T. Ishida (1999) Structural basis of inhibition of cysteine proteases by E-64 and its derivatives. Biopolymers, 51(1), 99­107.


Suppliers

Shandong SanYoung Industry Co., Ltd
SSI329013160
Bachem AG
N-1645.0005
Iris Biotech GmbH
LS-3890
Xingrui Industry Co., Limited
XIL272610904
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Prices & Availability




Data is processed


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Properties for L-trans-Epoxysuccinyl-Leu-4-guanidinobutylamide

Molecular Weight:
357.41 g·mol−1
Density:
~1.4 g/cm3 (Predicted)
Melting point:
265.96° C (Predicted)
Boiling point:
614.23° C (Predicted)
Solubility:
H2O: 20 mg/mL, clear, colorless
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Safety & Transport Information

Safety Codes:
S22 - Do not breathe dust
S24/25 - Avoid contact with skin and eyes
Storage temperature :
2-8°C
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Alternative Distributors of [L-trans-Epoxysuccinyl-Leu-4-guanidinobutylamide]

Producers or manufacturers change the product range from time to time. The following companies
have appeared as suppliers in the past / currently not verified

Chem-Impex International, Inc. | Alabiochem Tech. Co., Ltd. | Shanghai Hanhong Chemical Co., Ltd. | Gihi Chemicals Co., Limited

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