Temozolomide | CAS 85622-93-1 | Chemical-Suppliers

Element: temozolomide

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C-S » Chemicals » temozolomide-PX73887

Identification

Temozolomide

CAS:

85622-93-1

EINECS:

Molecular Formula:

C₆H₆N₆O₂

MDL:

MFCD00866492

SMILES:

CN1C(=O)N2C=NC(=C2N=N1)C(=O)N

Synonym:

temodar ; tzm ; m&b39831 ; m& ; nsc362856 ; ccrg81045 ; mb39831 ; 8-carbamoy ; b 39831 ; temozomide

Description

Temozolomide is an antitumor, antiangiogenic compound that has been shown to work by alkylating DNA, typically through addition of a methyl group to guanine in genomic DNA. The efficacy of this compound is dependent on its ability to methylate the DNA, thus triggering apoptosis; however, some cells are able to repair this damage via the enzymes O-6-methylguanine-DNA methyltransferase (MGMT). As a consequence, temozolomide is far more efficacious in tumor cells that have silenced this repair enzyme. Research has also been conducted to determine whether MGMT inhibitors such as O-6-benzylguanine might help to increase the efficacy of temozolomide. Furthermore, temozolomide has been implicated in causing arrest at the G₂/M cell cycle checkpoint, which might also play a role in its cytotoxicity.

Suppliers

Hunan Chemapi Biological Technology Co., Ltd.

HCBT5402700

Aozeal Certified Standards (AOCS), Inc.

T0022.00

Conscientia Industrial Co., Ltd (Zhejiang Conscientia Pharmaceutical)

CI8283312

Suan Farma, Inc

SFI180720

Quzhou Rundong Chemical Co., Ltd.

QRC3961584

Aecochem Corp.

AC168504

CSNpharm, Inc.

CSN12046

Hangzhou Lingrui Chemical Co., Ltd.

HLC4201680

Wanko Chemical Co., Ltd.

WC288864

Sigma-Aldrich International GmbH

SI3841152

scienTEST - bioKEMIX GmbH

S-B3001200

Finetech Industry Limited

FIL3001200

Carbone Scientific Co., Ltd.

CS3361008

Pharmacore Co., Limited

PL276828

AK Scientific, Inc.

AS228684

Xingrui Industry Co., Limited

XIL3481392

Capot Chemical Co., Ltd.

17413

Leap Chem Co., Ltd

LC216648

Santa Cruz Biotechnology, Inc.

203292

Dayang Chem (Hangzhou) Co.,Ltd.

DC3721488

Chemos GmbH & Co. KG

CC240720

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Prices & Availability

Data is processed

Properties for Temozolomide

Molecular Weight:

194.15 g·mol−1

Density:

1.97 g/cm³ (Predicted)

Melting point:

212°C dec.

Boiling point:

526.59° C at 760 mmHg (Predicted)

Solubility:

Soluble in water (5 mg/ml at 25° C), DMSO (39 mg/ml at 25° C), and ethanol (<1 mg/ml at 25° C).

Safety & Transport Information

Risk Codes:

R22 - Harmful if swallowed
R36/37/38 - Irritating to eyes, respiratory system and skin
R45 - May cause cancer
R46 - May cause inheritable genetic damage
R60 - May impair fertility
R61 - May cause harm to the unborn child

Safety Codes:

S24/25 - Avoid contact with skin and eyes
S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
S36 - Wear suitable protective clothing
S36/37 - Wear suitable protective clothing and gloves
S45 - In case of accident or if you feel unwell seek medical advice immediately (show the label where possible)
S53 - Avoid exposure - obtain special instructions before use

Hazard Symbols:

T, Xi

Storage temperature :

2-8°C

Alternative Distributors of [Temozolomide]

Producers or manufacturers change the product range from time to time. The following companies
have appeared as suppliers in the past / currently not verified