Simvastatin | CAS 79902-63-9 | Chemical-Suppliers

Element: simvastatin

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C-S » Chemicals » simvastatin-PX80514

Identification

Simvastatin

CAS:

79902-63-9

EINECS:

Molecular Formula:

C₂₅H₃₈O₅

MDL:

MFCD00072007

SMILES:

CCC(C)(C)C(=O)O[C@H]1C[C@H](C=C2[C@H]1[C@H]([C@H](C=C2)C)CC[C@@H]3C[C@H](CC(=O)O3)O)C

Synonym:

mk-0733 ; zocord ; simcor ; eucor ; zocor ; denan ; lipovas ; lipex ; mk-733 ; rechol

Description

Simvastatin is an HMGCR (HMG-CoA reductase) inhibitor with anti-proliferative properties. This compound has been shown to modulate purified bovine pituitary 20 S proteasome via mild stimulation of chymotrypsin-like activity and inhibition of peptidylglutamylpeptide hydrolyzing activity. Mechanistic studies suggest that Simvastatin decreases CDK4 and CDK2 kinase activities and represses high glucose-induced Rho A (Rho GTPase)/p21 signaling in mesangial cells. Simvastatin also potentiates apoptosis in human myeloid leukemia cells via the suppression of TNF-induced NF-κB activation (IC₅₀ ~ 13 µM).

Suppliers

Ambeed, Inc.

A198975

Aozeal Certified Standards (AOCS), Inc.

S0002.00

Conscientia Industrial Co., Ltd (Zhejiang Conscientia Pharmaceutical)

CI7593036

Lori Industry Co., Ltd

LI242726

Nantong Xindao Biotech Ltd

NXB2861144

ACIC Fine Chemicals Inc.

AFC2641056

Pharma Greven GmbH

PG198594

CellMark AB

CA121363

Xiamen Equation Chemical Co.,Ltd

XECC3521760

Sancai Industry Co.,Ltd.

SIC2641056

Arakato Development Ltd

AD253759

Aecochem Corp.

AC154462

CSNpharm, Inc.

CSN11927

Hangzhou Keying Chem Co., Ltd.

HKC3301320

Sigma-Aldrich International GmbH

SI3521056

scienTEST - bioKEMIX GmbH

S-B2751100

Finetech Industry Limited

FIL2751100

Carbone Scientific Co., Ltd.

CS308924

Hefei Hirisun Pharmatech Co., Ltd

HR012447

Iris Biotech GmbH

LS-1057.0000

AK Scientific, Inc.

AS209627

Xingrui Industry Co., Limited

XIL3191276

Leap Chem Co., Ltd

LC198594

Santa Cruz Biotechnology, Inc.

200829

Dayang Chem (Hangzhou) Co.,Ltd.

DC3411364

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CAS equal suppliers

MK-733

ShangHai Biochempartner Co., Ltd.

BCP06293

MK-733

Excenen Pharmatech Co., Ltd.

EN-3769

Liponorm

Hangzhou J&H Chemical Co., Ltd.

HJC248992

Diatomaceous earth

Simagchem Corporation

SC7562268

Simvastatin, Pharma

Salsbury Chemicals, Inc.

SC9122736

2,2-Dimethlbutanoic acid 1,2,3,7,8,8a-hexahydro-3,7-dimethl-8-[2-tetrahyddro-4-hydroxy-2-oxo-2H-pydran-yl]-1-naphthalenyl ester

Iris Biotech GmbH

LS-1057

(1S,3R,7S,8S,8aR)-8-(2-((2R,4R)-4-Hydroxy-6-oxotetrahydro-2H-pyran-2-yl)ethyl)-3,7-dimethyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl 2,2-dimethylbutanoate

Wanko Chemical Co., Ltd.

WC76104228312

(1S,3R,7S,8S,8aR)-8-(2-((2R,4R)-4-Hydroxy-6-oxotetrahydro-2H-pyran-2-yl)ethyl)-3,7-dimethyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl 2,2-dimethylbutanoate

BLD Pharmatech Ltd

BP57078171234

Prices & Availability

Data is processed

Properties for Simvastatin

Molecular Weight:

418.57 g·mol−1

Density:

1.11 g/cm³

Melting point:

139 °C

Boiling point:

564.86° C at 760 mmHg

Solubility:

Soluble in DMSO (>25 mg/ml), ethanol (>25 mg/ml), water (0.03 mg/l), and methanol.

Safety & Transport Information

Risk Codes:

R36/37/38 - Irritating to eyes, respiratory system and skin

Safety Codes:

S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
S36 - Wear suitable protective clothing

Hazard Classes:

Hazard Symbols:

Storage temperature :

0-6°C

RID/ADR certification :

3077

Alternative Distributors of [Simvastatin]

Producers or manufacturers change the product range from time to time. The following companies
have appeared as suppliers in the past / currently not verified