Rapamycin | CAS 53123-88-9 | Chemical-Suppliers

Element: rapamycin

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C-S » Chemicals » rapamycin-PX77934

Identification

Rapamycin

CAS:

53123-88-9

EINECS:

Molecular Formula:

C₅₁H₇₉NO₁₃

MDL:

MFCD00867594

SMILES:

CC1CCC2CC(C(=CC=CC=CC(CC(C(=O)C(C(C(=CC(C(=O)CC(OC(=O)C3CCCCN3C(=O)C(=O)C1(O2)O)C(C)CC4CCC(C(C4)OC)O)C)C)O)OC)C)C)C)OC

Synonym:

Description

Rapamycin is a member of the macrolide immunosuppressant family and a FRAP inhibitor. Rapamycin exhibits binding and inhibitory actions to the FK506 binding protein (FKBP5) proline rotamase via simultaneous binding by FKBP12 and FRAP. FRAP (RAFT1) proteins exhibit homology to PI 4- and PI 3-kinases, which have PI 4-kinase and autophosphorylating activities.The rapamycin/FKBP complex does not inhibit the FRAP PI 4-kinase activity, but does inhibit FRAP autophosphorylation. Rapamycin is unique in its ability to inhibit lymphokine induced cell proliferation at the G₁ and S phase as well as an irreversible cellular arrest at the G₁ phase in S. cerevisiae cells. It also exhibits selective signal blocking leading to the activation of p70/85 S6 kinase, which is potentially due to the inhibition of FRAP autophosphorylation or protein kinase activity. Angiogenesis inhibition is also exhibited, possibly through the inhibition of the Akt pathway. Rapamycin is an inhibitor of mTOR.

Suppliers

Ambeed, Inc.

A656002

Aea.ltd

A63126

OPQ Chemical Co., Ltd

OC189567

Aozeal Certified Standards (AOCS), Inc.

S0013.00

Create Chemical Co., Ltd.

CC225675

Conscientia Industrial Co., Ltd (Zhejiang Conscientia Pharmaceutical)

CI6212484

Shandong Minglang Chemical Co., Ltd

SMC3151260

Lori Industry Co., Ltd

LI198594

Refine Chemical Co.,Ltd.

RCC216864

Shandong Lanhai Industry Co.,Ltd.

SLIC2971485

Unilong Industry Co.,Ltd

UIC216864

JieJie Group Co., Ltd.

JG198594

A.G. Scientific

AS135405

Guangzhou Topwork Chemical Co., Ltd.

GTC3241296

Hangzhou Cherry Pharmaceutical Technology Co., Ltd.

HCPT4592295

X´ian Taicheng Chem Co., Ltd

XTC2611044

Hangzhou Verychem Science & Technology Co., Ltd.

HVST4322160

Xiamen Equation Chemical Co.,Ltd

XECC2881440

Sancai Industry Co.,Ltd.

SIC216864

Aecochem Corp.

AC126378

CSNpharm, Inc.

CSN16385

Hangzhou Keying Chem Co., Ltd.

HKC2701080

Sigma-Aldrich International GmbH

SI288864

scienTEST - bioKEMIX GmbH

S-B225900

Finetech Industry Limited

FIL225900

Carbone Scientific Co., Ltd.

CS252756

Pharmacore Co., Limited

PL207621

Hefei Hirisun Pharmatech Co., Ltd

HR011428

Iris Biotech GmbH

LS-1056

CM Fine Chemicals

CFC153612

AK Scientific, Inc.

AS171513

Xingrui Industry Co., Limited

XIL2611044

Capot Chemical Co., Ltd.

16645

Zehao Industry Co., Ltd.

ZI216648

Amadis Chemical Company Limited

ACCL2791395

Leap Chem Co., Ltd

LC162486

Santa Cruz Biotechnology, Inc.

3504

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(3S,6R,7E,9R,10R,12R,14S,15E,17E,19E,21S,23S,26R,27R,34aS)-9,10,12,13,14,21,22,23,24,25,26,27,32,33,34,34a-Hexadecahydro-9,27-dihydroxy-3-[(1R)-2-[(1S,3R,4R)-4-hydroxy-3-methoxycyclohexyl]-1-methyleth

BLD Pharmatech Ltd

BP108000324000

Prices & Availability

Data is processed

Properties for Rapamycin

Molecular Weight:

914.17 g·mol−1

Density:

1.18 g/cm³ (Predicted)

Melting point:

183-185° C

Boiling point:

973.02° C at 760 mmHg (Predicted)

Solubility:

Soluble in DMSO (25 mg/ml), ethanol (up to 50 mg/ml), chloroform (5 mg/ml), methanol (25 mg/ml), ether, and acetone. Insoluble in water.

Safety & Transport Information

coming up soon

Alternative Distributors of [Rapamycin]

Producers or manufacturers change the product range from time to time. The following companies
have appeared as suppliers in the past / currently not verified