POM 1(Sodium polyoxotungstate) belongs to a group of polyoxotungstates that inhibits CD39, CD39L1, CD39L3 (nucleoside-triphosphate-diphosphohydrolases). POM 1 is a non-specific inhibitor of NTPDase8 (ecto-nucleoside-triphosphate-diphosphohydrolases) and has been observed to inhibit renal protection activated through ischemic preconditioning (IP). This compound displays minor selectivity for NTPDases 1 and 2 over NTPDase 3 (Ki values are 2.58 vs 28.8 μM, respectively). Studies have shown that POM 1 is more potent at blocking ATP breakdown than ARL 67156 in cerebellar slices and can also block central synaptic transmission, which is independent of the NTPDase inhibition. POM 1 is the anhydrous form of sc-253591. POM 1 is an inhibitor of P2Y12.
Specific target organ toxicity following single exposure, category 3
- Respiratory tract irritation
- Narcotic effects
Not used
with the "skull and crossbones" pictogram
for skin or eye irritation if:
the "corrosion" pictogram also appears
the "health hazard" pictogram is used to indicate respiratory sensitization
Safety & Transport Information
Risk Codes:
R22 - Harmful if swallowed R41 - Risk of serious damage to eyes R52/53 - Harmful to aquatic organisms, may cause long-term adverse effects in the aquatic environment
Safety Codes:
S22 - Do not breathe dust S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice S39 - Wear eye/face protection S61 - Avoid release to the environment. Refer to special instructions/safety data sheet
Hazard Symbols:
Xn
Storage temperature :
Store at RT
x
Alternative Distributors of [POM 1]
Producers or manufacturers change the product range from time to time. Currently there are no other manufacturers known.
Element: 
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