SR 33805 oxalate | CAS 121346-32-5

Element: oxalate 33805

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C-S » Chemicals » oxalate-PX78756

Identification

SR 33805 oxalate

CAS:

121346-32-5

EINECS:

Molecular Formula:

C₃₂H₄₀N₂O₅S.C₂H₂O₄

MDL:

MFCD00919219

SMILES:

CC(C)C1=C(NC2=CC=CC=C21)S(=O)(=O)C3=CC=C(C=C3)OCCCN(C)CCC4=CC(=C(C=C4)OC)OC.C(C(=O)O)C(=O)O

Synonym:

n-(3,4-dimethoxyphenethyl)-3-(4-(3-isopropyl-1-methyl-1h-indol-2-ylsulfonyl)phenoxy)-n-methylpropan-1-amine ; 3,4-dimethoxy-n-methyl-n-(3-(4-((1-methyl-3-(1-methylethyl)-1h-indol-2-yl)sulfonyl)phenoxy)propyl)benzeneethanamineoxal] ; n-(3,4-dimethoxyphenethyl)-3-(4-((3-isopropyl-1-methyl-1h-indol-2-yl)sulfonyl)phenoxy)-n-methylpr ; 3,4-dimethoxy-n-methyl-n-[3-[4-[[1-methyl-3-(1-methylethyl)-1h-indol-2-yl]sulfonyl]phenoxy]propyl]benzeneethanamine oxalate ; 3,4-dimethoxy-n-methyl-n-[3-[4-[[1-methyl-3-(1-methylethyl)-1h-indol-2-yl]sulfonyl]phenoxy]propyl]benzeneethanamine ; sr 33805 oxalate

Description

SR 33805 oxalate is a potent calcium channel protein inhibitor. SR 33805 oxalate binds allosterically to a1-subunit of L-type Ca²⁺ channels (K_d = 20 pM), at a site distinct from other types of blocker. SR 33805 oxalate shows some selectivity for vascular smooth muscle, inducing vasorelaxation without producing inotropic or chronotropic effects. SR 33805 oxalate inhibits PDGF-stimulated smooth muscle cell proliferation.