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Nobiletin

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Formula: C21H22O8
CAS: 478-01-3
search Element: nobiletin

Identification

Structural Formula
Nobiletin
CAS:
478-01-3
EINECS:
Molecular Formula:
C21H22O8
MDL:
MFCD03273560
SMILES:
COC1=C(C=C(C=C1)C2=CC(=O)C3=C(O2)C(=C(C(=C3OC)OC)OC)OC)OC
Synonym:
hexamethoxyflavone ; biletin ; 5,6,7,8-tetramethoxy- ; chuanpi glycosides ; nobiletin ; nobiletin , hexamethoxyflavone ; nobiletin, >=98% ; nobiletin with hplc ; nobiletin, 20% (technical grade) ; 3',4',5,6,7,8-hexamethoxyflavone


Description

Nobiletin is a flavanoid with antioxidant and anti-inflammatory properties found in the rind of tangerines. The compound has been observed to inhibit the phosphorylation of MEK (mitogen-activated protein kinase). Nobiletin has also been documented to suppress the expression of MMP-1 (matrix metalloproteinases), MMP-3 and MMP-9 that are involved in the breakdown of the extracellular matrix during tumor metastasis. In vitro studies of Nobiletin on varying cancer cell lines and on the chick egg has shown the anti-angiogenic effects of Nobiletin through down regulation of ERK 1, ERK 2 and c-Jun N-terminal kinase, and transcriptional factors c-Jun and Stat3. The compound also suppressed proliferation, migration and tube formation on matrigel of HUVEC cells stimulated with growth supplement. Nobiletin has demonstrated to attenuate NF-κB transcriptional activation, NO and PGE2 production, NOS2 (inducible nitric oxide synthase) and Cox-2 (cyclooxygenase-2) expression.


Suppliers

Autech Industry Co.,Limited
AIC243972
Chengdu Pufeide Biotech. Co., Ltd
CPB2971188
H&Z Industry Co.,Ltd
HIC180720
Conscientia Industrial Co., Ltd (Zhejiang Conscientia Pharmaceutical)
CI6212484
Chemlyte Solutions
CS162486
Indofine Chemical Co, Inc.
06-022N
Sinogreat Enterprise Ltd.
SE225675
Sancai Industry Co.,Ltd.
SIC216864
CSNpharm, Inc.
CSN19425
Hangzhou Lingrui Chemical Co., Ltd.
HLC3151260
Finetech Industry Limited
FIL225900
Carbone Scientific Co., Ltd.
CS252756
Acinopeptide Co., Ltd.
A198396
Hefei Hirisun Pharmatech Co., Ltd
HR013187
Xingrui Industry Co., Limited
XIL2611044
BOC Sciences
BS108324
Leap Chem Co., Ltd
LC162486
Santa Cruz Biotechnology, Inc.
202733
Dayang Chem (Hangzhou) Co.,Ltd.
DC2791116
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CAS equal suppliers

PMF
Simagchem Corporation
SC63189
PMF
Xiamen Equation Chemical Co.,Ltd
XECC96480
nobiletin with hplc
Indofine Chemical Co, Inc.
021348S
3',4',5,6,7,8-Hexamethoxyflavone
CM Fine Chemicals
CFC16326528
nobiletin, 20% (technical grade)
Indofine Chemical Co, Inc.
06-022
2-(3,4-Dimethoxyphenyl)-5,6,7,8-tetramethoxy-4H-chromen-4-one
Gihi Chemicals Co., Limited
GCL988239528
2-(3,4-Dimethoxyphenyl)-5,6,7,8-tetramethoxy-4H-chromen-4-one
BLD Pharmatech Ltd
BP658819764

Prices & Availability




Data is processed


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Properties for Nobiletin

Molecular Weight:
402.39 g·mol−1
Density:
1.25 g/cm3 (Predicted)
Melting point:
136-140° C
Boiling point:
587.93° C at 760 mmHg (Predicted)
Solubility:
Soluble in methanol ( ), water (<1 mg/ml), chloroform, DMSO (81 mg/ml), and ethanol (3 mg/ml).
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Safety & Transport Information

Storage temperature :
-20 °C
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Alternative Distributors of [Nobiletin]

Producers or manufacturers change the product range from time to time. The following companies
have appeared as suppliers in the past / currently not verified

3B Scientific Corporation | Shanghai Tauto Biotech Co., Ltd. | China Risesun Group Co., Ltd. | ChengDu KaiXin Technology Development Co., Ltd. | Chengdu Qiaofeng Technological Development Co., Ltd. | Jinan Great Chemical Co., Ltd. | East Chemical Industry Co., Ltd. | Cfm Oskar Tropitzsch GmbH | BioBioPha Co., Ltd. | Chengdu Conut Intl. Co., Ltd. | BOC Sciences | All Right Chemical Co., Ltd. | Suzhou Vosun Chemical Co.,Ltd. | Gihi Chemicals Co., Limited | Clearsynth Canada INC.

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