Nilotinib | CAS 641571-10-0 | Chemical-Suppliers

Element: nilotinib

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C-S » Chemicals » nilotinib-PX81616

Identification

Nilotinib

CAS:

641571-10-0

EINECS:

Molecular Formula:

C₂₈H₂₂F₃N₇O

MDL:

MFCD09833716

SMILES:

CC1=C(C=C(C=C1)C(=O)NC2=CC(=CC(=C2)N3C=C(N=C3)C)C(F)(F)F)NC4=NC=CC(=N4)C5=CN=CC=C5

Synonym:

Description

Nilotinib is a small molecule Bcr-Abl kinase inhibitor, rationally designed to bind and inhibit the c-Abl kinase active site with more affinity than the prototypic Bcr-Abl kinase inhibitor Imatinib. Nilotinib demonstrates a high affinity for the kinase (IC₅₀ < 30nM) and shows efficacy against chronic myelogenous leukemias (CML) expressing the Bcr-Abl oncogene/fusion protein, both the wild type and CMLs presenting Imatinib resistance.

Suppliers

Aea.ltd

A63126

Shandong SanYoung Industry Co., Ltd

SSI3151260

Ambeed, Inc.

A448494

Aozeal Certified Standards (AOCS), Inc.

N0036.00

Conscientia Industrial Co., Ltd (Zhejiang Conscientia Pharmaceutical)

CI6212484

Xiamen Equation Chemical Co.,Ltd

XECC2881440

CSNpharm, Inc.

CSN11559

Hangzhou Lingrui Chemical Co., Ltd.

HLC3151260

Wanko Chemical Co., Ltd.

WC216648

Finetech Industry Limited

FIL225900

Pharmacore Co., Limited

PL207621

CM Fine Chemicals

CFC153612

AK Scientific, Inc.

AS171513

Xingrui Industry Co., Limited

XIL2611044

Capot Chemical Co., Ltd.

18272

BOC Sciences

BS108324

Leap Chem Co., Ltd

LC162486

Santa Cruz Biotechnology, Inc.

202245

Get Quick Quote

CAS equal suppliers

AMN-107

Aea.ltd

A4998

Nilotinib-d3

Santa Cruz Biotechnology, Inc.

sc-219376

Nilotinib;AMN-107

Excenen Pharmatech Co., Ltd.

EN-0496

4-methyl-3-((4-(3-pyridinyl)-2-pyrimidinyl)amino)-n-(5-(4-methyl-1h-imidazol-1-yl)-3-(trifluoromethyl)phenyl)benzamide

Hangzhou J&H Chemical Co., Ltd.

HJC62186248744

Prices & Availability

Data is processed

Properties for Nilotinib

Molecular Weight:

529.5 g·mol−1

Density:

1.36 g/cm³ (Predicted)

Melting point:

230-242° C

Solubility:

Soluble in DMSO (50 mg/mL), chloroform, DMF (~3 mg/mL), water(very poorly soluble, maximum solubility in plain water is estimated to be about 10-20 µM; buffers, serum, or other additives may increase or decrease the aqueous solubility), and ethanol(very poorly soluble).

Hazard Statements

GHS03
Harmful

Acute toxicity (oral, dermal, inhalation), category 4
Skin irritation, categories 2, 3
Eye irritation, category 2A
Skin sensitization, category 1
Specific target organ toxicity following single exposure, category 3
- Respiratory tract irritation
- Narcotic effects

Not used

with the "skull and crossbones" pictogram
for skin or eye irritation if:
the "corrosion" pictogram also appears
the "health hazard" pictogram is used to indicate respiratory sensitization

GHS08
Health hazard

Respiratory sensitization, category 1
Germ cell mutagenicity, categories 1A, 1B, 2
Carcinogenicity, categories 1A, 1B, 2
Reproductive toxicity, categories 1A, 1B, 2
Specific target organ toxicity following single exposure, categories 1, 2
Specific target organ toxicity following repeated exposure, categories 1, 2
Aspiration hazard, categories 1, 2

Safety & Transport Information

Alternative Distributors of [Nilotinib]

Producers or manufacturers change the product range from time to time. The following companies
have appeared as suppliers in the past / currently not verified