IPA 3

IPA 3 is a selective cell permeable α PAK (Pak1, group I p21-activated kinase) inhibitor which functions by inhibiting activators from binding to the active sites on the enzyme. α PAK contains autoinhibitory regions that suppress the catalytic activity of its kinase domain, which are removed once activators have bound to the protein. In addition, IPA 3 does not inhibit α PAK if activators are already bound to the enzyme. Furthermore, IPA 3 can inhibit the activity of α PAK isomers that are structurally similar by autoinhibition. It is a potential antitumor agent.