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Indirubin

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Formula: C16H10N2O2
CAS: 479-41-4
search Element: indirubin

Identification

Structural Formula
Indirubin
CAS:
479-41-4
EINECS:
Molecular Formula:
C16H10N2O2
MDL:
SMILES:
C1=CC=C2C(=C1)/C(=C/3C(=O)C4=CC=CC=C4N3)/C(=O)N2
Synonym:
2-ylidene)-1,3-dihydro- ; indirubin (rg) ; nsc105327 ; indigo red ; indigopurpurin ; c.i.73200 ; c.i.75790 ; indirubin , couroupitine b ; couroupitine b ; indirubin


Description

Indirubin, also known as isoindigotin, is an inhibitor of cyclin-dependent kinases (CDK1/cyclin B (IC50 = 10µM), CDK2/cyclin A (IC50 = 2.2µM), CDK2/cyclin E (IC50 = 7.5µM), CDK4/cyclin D1 (IC50 = 12µM), CDK5/p35 (IC50 = 5.5µM)) and of GSK-3β (IC50 = 600nM). Studies investigating functional isoindigos show that they have the ability to disrupt cell growth and proliferation. The compound is a potent aryl hydrocarbon receptor ligand and is found in human urine and fetal bovine serum. Synthesized isoindigo-based oligothiophenes are used to study heterojunction solar cells. Shown to inhibit allergic contact dermatitis by regulating T helper mediated immune system in a DNCB-induced model.


Suppliers

Chengdu Pufeide Biotech. Co., Ltd
CPB2971188
H&Z Industry Co.,Ltd
HIC180720
Chemlyte Solutions
CS162486
Indofine Chemical Co, Inc.
06-713
CSNpharm, Inc.
CSN19364
Carbone Scientific Co., Ltd.
CS252756
Xingrui Industry Co., Limited
XIL2611044
BOC Sciences
BS108324
Leap Chem Co., Ltd
LC162486
Santa Cruz Biotechnology, Inc.
201531
Dayang Chem (Hangzhou) Co.,Ltd.
DC2791116
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CAS equal suppliers

3-(1,3-dihydro-3-oxo-2h-indol-2-ylidene)-1,3-dihydro-2h-indol-2-on
Capot Chemical Co., Ltd.
35044
3-(1,3-Dihydro-3-oxo-2H-indol-2-ylidene)-1,3-dihydro-2H-indol-2-one
Salsbury Chemicals, Inc.
SC1447243416
2H-indol-2-one, 3-(1,3-dihydro-3-oxo-2h-indol-2-ylidene)-1,3-dihydro-
Angene International Limited
AGN-PC-0LPZ6R

Prices & Availability




Data is processed


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Properties for Indirubin

Molecular Weight:
262.26 g·mol−1
Solubility:
Soluble in DMSO(warmed) (>2 mg/ml).
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Hazard Statements

GHS07

GHS03
Harmful
  • Acute toxicity (oral, dermal, inhalation), category 4
  • Skin irritation, categories 2, 3
  • Eye irritation, category 2A
  • Skin sensitization, category 1
  • Specific target organ toxicity following single exposure, category 3
    - Respiratory tract irritation
    - Narcotic effects
  • Not used
  • with the "skull and crossbones" pictogram
  • for skin or eye irritation if:
  • the "corrosion" pictogram also appears
  • the "health hazard" pictogram is used to indicate respiratory sensitization

Safety & Transport Information

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Alternative Distributors of [Indirubin]

Producers or manufacturers change the product range from time to time. The following companies
have appeared as suppliers in the past / currently not verified

Cfm Oskar Tropitzsch GmbH | BOC Sciences | Jinan Great Chemical Co., Ltd. | Gihi Chemicals Co., Limited | 3B Scientific Corporation | Excenen Pharmatech Co., Ltd. | HuaiBei SanHe Developing Co., Ltd. | Shanghai Tauto Biotech Co., Ltd. | Jinan Haohua Industry Co., Ltd. | Nantong Chem-Tech. (Group) Co., Ltd. | ChengDu KaiXin Technology Development Co., Ltd. | Chengdu Qiaofeng Technological Development Co., Ltd. | ShangHai Biochempartner Co., Ltd. | Shanxi Zishan Natural Technology Co., Ltd. | East Chemical Industry Co., Ltd. | Aopharm

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