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HBTU

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Formula: C11H16N5O.PF6
CAS: 94790-37-1
search Element: hbtu
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Identification

Structural Formula
HBTU
CAS:
94790-37-1
EINECS:
Molecular Formula:
C11H16N5O.PF6
MDL:
MFCD00075445
SMILES:
CN(C)C(=[N+](C)C)ON1C2=CC=CC=C2N=N1.F[P-](F)(F)(F)(F)F
Synonym:
hbtu-reagent ; hbtu >=98.0% (t) ; hbtu [o-benzotriazole-n ; hbtu,99% ; o-benzotriazole-n,n ; hbtu polymer bound ; o-benzotriazol-1-yl-tetramethyluronium ; hbtu ; hexafluorophosphate hbtu ; n'-tetramethyl-uronium-hexafluoro-phosphate]


Description

HBTU is a commonly used coupling reagent, and can be used in solid phase peptide synthesis. It is reported to convert carboxylic acids into azides efficiently and practically. This process may be used with a wide range of carboxylic acids including N-protected amino acids. It has also been reported to be useful in one-pot synthesis of dipeptidyl urea esters, ureas, and carbamates from acids.


Suppliers

Krada CPS Industry S.L
KCIS88440
+
OPQ Chemical Co., Ltd
OC84252
+
Shandong SanYoung Industry Co., Ltd
SSI140560
+
Shandong Ench Chemical Co.,Ltd
SECC120600
+
Lori Industry Co., Ltd
LI88264
+
Shandong Lanhai Industry Co.,Ltd.
SLIC132660
+
Kingreat Chemistry Company Limited
KCCL136680
+
Changzhou Union Chemicals Co.,Ltd.
CUCC136680
+
Advanced Chemtech, Inc. USA
ACU108432
Xiamen Equation Chemical Co.,Ltd
XECC128640
+
Sancai Industry Co.,Ltd.
SIC96384
+
Reafon Industry Co., Ltd.
RF-C129
+
Reafon Industry Co., Ltd.
RI100300
+
Hangzhou Keying Chem Co., Ltd.
HKC120480
+
scienTEST - bioKEMIX GmbH
S-B100400
+
Finetech Industry Limited
FIL100400
+
AK Scientific, Inc.
AS76228
+
Simagchem Corporation
SC84252
+
Capot Chemical Co., Ltd.
12720
+
Zehao Industry Co., Ltd.
ZI96288
+
Amadis Chemical Company Limited
ACCL124620
+
Santa Cruz Biotechnology, Inc.
203074
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Hangzhou Verychem Science & Technology Co., Ltd.
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H&Z Industry Co.,Ltd
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Allfluoro Pharmaceutical Co. Ltd.
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Gihi Chemicals Co., Limited
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CM Fine Chemicals
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Acinopeptide Co., Ltd.
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Leap Chem Co., Ltd
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Hangzhou J&H Chemical Co., Ltd.
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Hangzhou Zhongqi Chem Co., Ltd
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Iris Biotech GmbH
RL-1030.0100
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Wanko Chemical Co., Ltd.
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Ascender Chemical Co.,Ltd
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Puyer BioPharma Ltd.
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Skyrun Industrial Co., Ltd.
SI985529565
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GL Biochem (Shanghai) Ltd.
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HBTU [O-Benzotriazole-N,N,N',N'-tetramethyl-uronium-hexafluoro-phosphate]
Iris Biotech GmbH
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Molekula
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Alfa (A Johnson Matthey Company)
A1996859904
2-(1H-Benzotriazol-1-Yl)-1,1,3,3-Tetramethyl Uronium Hexafluoro Phosphate(Hbtu)
DKSH International AG
DIA1493159724
2-(1H-Benzotriazole-1-yl)-1,1,3,3-tetramethyluronium hexafluorophosphate (HBTU)
Carbone Scientific Co., Ltd.
CS1548446452
[Benzotriazol-1-yloxy(dimethylamino)methylene]-dimethyl-ammonium hexafluorophosphate
Manchester Organics Limited
D50121
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BLD Pharmatech Ltd
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O-(Benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium Hexafluorophosphate [Coupling Reagent for Peptide]
TCI Chemicals (India) Pvt. Ltd.
B1657

Prices & Availability




Data is processed


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Properties for HBTU

Molecular Weight:
379.24 g·mol−1
Melting point:
200 °C (dec.)(lit.)
Flash point:
200°C
Solubility:
acetonitrile: 0.1 g/mL, clear
x

Hazard Statements

GHS07

GHS03
Harmful
  • Acute toxicity (oral, dermal, inhalation), category 4
  • Skin irritation, categories 2, 3
  • Eye irritation, category 2A
  • Skin sensitization, category 1
  • Specific target organ toxicity following single exposure, category 3
    - Respiratory tract irritation
    - Narcotic effects
    • Not used
  • with the "skull and crossbones" pictogram
  • for skin or eye irritation if:
  • the "corrosion" pictogram also appears
  • the "health hazard" pictogram is used to indicate respiratory sensitization

Safety & Transport Information

Risk Codes:
R20/21/22 - Harmful by inhalation, in contact with skin and if swallowed
R36/37/38 - Irritating to eyes, respiratory system and skin
R42/43 - May cause sensitization by inhalation and skin contact
Safety Codes:
S22 - Do not breathe dust
S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
S36 - Wear suitable protective clothing
S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection
Hazard Symbols:
Xi, Xn
Hazard symbol Xn Hazard symbol Xi
Storage temperature :
2-8°C
x

Alternative Distributors of [HBTU]

Producers or manufacturers change the product range from time to time. The following companies
have appeared as suppliers in the past / currently not verified

Huasheng Chemical Co., Limited | Shanghai International Pharmaceutical Co., Ltd. | Suzhou Tianma Specialty Chemicals Co., Ltd. | Shanghai Eagle Chemical Co., Ltd. | AGTC Bioproducts Ltd. | AA Biochem Inc. | Hongda Group Limited | Pharmasi Chemicals Co., Ltd. | Suzhou Rovathin Pharmatech Co., Ltd | Chemrio International Limited | Ubichem PLC | Share Chemical Co., Ltd. | Shanghai Hanhong Chemical Co., Ltd. | Shijiazhuang JuSha Imp.& Exp. Co.Ltd | AOKBIO Co., Ltd. | Nantong Qihai Chemicals Co., Ltd. | Rif Life Science Co., Limited | East Chemical Industry Co., Ltd. | Zhejiang Kaili Industrial Co., Ltd. | Suzhou Bichal Biological Technology Co., Ltd. | Hangzhou Ocean Chemical Co., Ltd. | Jinan Haohua Industry Co., Ltd. | Suzhou Vosun Chemical Co.,Ltd. | Sino Rarechem Labs Co. Ltd. | Xiamen Hisunny Chemical Co., Ltd. | scienTEST | Changzhou Union Chemicals Co.,Ltd.

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