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Genistein

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Formula: C15H10O5
CAS: 446-72-0
search Element: genistein

Identification

Structural Formula
Genistein
CAS:
446-72-0
EINECS:
207-174-9
Molecular Formula:
C15H10O5
MDL:
MFCD00016952
SMILES:
C1=CC(=CC=C1C2=COC3=CC(=CC(=C3C2=O)O)O)O
Synonym:
gen ; prunetol ; glyciten ; genivida ; npi 031l ; c.i.75610 ; genisteol ; genistein ; genestein ; bonistein


Description

Genistein, a phytoestrogen found in soy products, is a highly specific inhibitor of protein tyrosine kinase (PTK). Additionally, Genistein is a competitive inhibitor of ATP in other protein kinase reactions. Genistein inhibits tyrosine phosphorylation in isolated enzyme and receptor preparations and in whole cells including platelets, lymphocytes and a variety of cultured cells. It also inhibits EGF-stimulated phosphorylation in cultured cells as well as inhibition of Topo II (topoisomerase II). In cultured A431 epidermoid carcinoma cells, EGF-stimulated tyrosine phosphorylation was completely inhibited by genistein at 100 μg/ml. Inhibition is competitive with ATP and noncompetitive with substrate. Genistein also acts as an agonist at the GPR30 receptor and binds to PPARγ and estrogen receptors. Genistein also binds to PPARγ, acting as an agonist at this receptor and has been shown to acitvate CFTR (cystic fibrosis transmembrane conductance regulator) chlorine channels in some studies. Genistein is an inhibitor of Glucosidase.


Suppliers

Conscientia Industrial Co., Ltd (Zhejiang Conscientia Pharmaceutical)
CI6212484
Chengdu Pufeide Biotech. Co., Ltd
CPB2971188
Shandong Ench Chemical Co.,Ltd
SECC2701350
H&Z Industry Co.,Ltd
HIC180720
Autech Industry Co.,Limited
AIC243972
Ambeed, Inc.
A107459
Chemlyte Solutions
CS162486
Indofine Chemical Co, Inc.
G-103
A.G. Scientific
AS135405
Chematek S.p.A.
CS135405
Sinogreat Enterprise Ltd.
SE225675
X´ian Taicheng Chem Co., Ltd
XTC2611044
Xiamen Equation Chemical Co.,Ltd
XECC2881440
Aecochem Corp.
AC126378
CSNpharm, Inc.
CSN18651
Hangzhou Lingrui Chemical Co., Ltd.
HLC3151260
Sigma-Aldrich International GmbH
SI288864
scienTEST - bioKEMIX GmbH
S-B225900
Finetech Industry Limited
FIL225900
Pharmacore Co., Limited
PL207621
Iris Biotech GmbH
LS-1032.0000
AK Scientific, Inc.
AS171513
Xiamen Kinbester Co., Ltd.
XK234702
Simagchem Corporation
SC189567
Xingrui Industry Co., Limited
XIL2611044
BOC Sciences
BS108324
Leap Chem Co., Ltd
LC162486
Santa Cruz Biotechnology, Inc.
3515
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Iris Biotech GmbH
LS-1032
4',5,7-Trihydroxyisoflavone
Shandong SanYoung Industry Co., Ltd
SSI18907560
Genistein ( 4',5,7-Trihydroxyisoflavone)
Medibro Corporation Limited
MCL332113284
4H-1-benzopyran-4-one, 5,7-dihydroxy-3-(4-hydroxyphenyl)-
Angene International Limited
AGN-PC-00GV2H
4',5,7-Trihydroxyisoflavone; 5,7-Dihydroxy-3-(4-hydroxyphenyl)-4H-1-benzopyran-4-one
Shanghai UCHEM Inc.
UCHEM-4546

Prices & Availability




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Properties for Genistein

Molecular Weight:
270.24 g·mol−1
Density:
1.55 g/cm3
Melting point:
297-298 °C
Boiling point:
555.51° C at 760 mmHg
Solubility:
DMSO: soluble
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Safety & Transport Information

Risk Codes:
R22 - Harmful if swallowed
R36/38 - Irritating to eyes and skin
Safety Codes:
S22 - Do not breathe dust
S24/25 - Avoid contact with skin and eyes
S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
Hazard Classes:
irritant
Hazard Symbols:
Xi, Xn
Hazard symbol Xn Hazard symbol Xi
Storage temperature :
-20°C
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Alternative Distributors of [Genistein]

Producers or manufacturers change the product range from time to time. The following companies
have appeared as suppliers in the past / currently not verified

Spectrum Chemical Mfg. Corp. | Advance Scientific & Chemical, Inc. | Molekula GmbH | HuaiBei SanHe Developing Co., Ltd. | 3B Scientific Corporation | Northchem (Tianjin) International Trading Co., Ltd. | Hangzhou FST Pharmaceutical Co., Ltd. | Xi´an Jiangxing Biotechnique Co., Ltd. | Nantong Chem-Tech. (Group) Co., Ltd. | Pharmasi Chemicals Co., Ltd. | TCI Europe NV | Shanghai Honghao Chemicals Co., Ltd. | New Dragon Industrial Co., Ltd | Hefei Photochem Trading Co., Ltd | Borun Chemical Co., Ltd. | Chengdu Biopurify Phytochemicals Ltd. | Discovery Fine Chemicals Limited | Chengdu Qiaofeng Technological Development Co., Ltd. | Shanghai AOKChem Group Limited | Hangzhou Think Chemical Co., Ltd. | Suzhou Rovathin Pharmatech Co., Ltd | Xi´an Union Pharmpro Co., Ltd. | Shanghai Brightol International Co., Ltd. | Shanghai Tauto Biotech Co., Ltd. | Lanospharma Laboratories Co., Ltd. | Baoji Herbest Bio-Tech Co., Ltd. | Jinan Great Chemical Co., Ltd. | Tai Hua Industries Co., Limited | Carl Roth GmbH + Co KG | East Chemical Industry Co., Ltd. | Watson International Ltd | Cfm Oskar Tropitzsch GmbH | BioBioPha Co., Ltd. | Greenlife Biotechnology Co.,Ltd. | Chengdu Conut Intl. Co., Ltd. | BOC Sciences | Taizhou Creating Chemical Co., Ltd. | Fermentek Ltd. | Jinan Haohua Industry Co., Ltd. | Suzhou Vosun Chemical Co.,Ltd. | Pfaltz & Bauer, Inc. | Xiamen Hisunny Chemical Co., Ltd. | scienTEST | Gihi Chemicals Co., Limited

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