FURA 2/AM | CAS 108964-32-5 | Chemical-Suppliers

Element: fura

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C-S » Chemicals » fura-PX79003

Identification

FURA 2/AM

CAS:

108964-32-5

EINECS:

Molecular Formula:

C₄₄H₄₇N₃O₂₄

MDL:

MFCD00036976

SMILES:

CC1=CC(=C(C=C1)N(CC(=O)OCOC(=O)C)CC(=O)OCOC(=O)C)OCCOC2=C(C=CC3=C2C=C(O3)C4=NC=C(O4)C(=O)OCOC(=O)C)N(CC(=O)OCOC(=O)C)CC(=O)OCOC(=O)C

Synonym:

fura-2 acetoxymethyl ; fura 2 acetoxymethyl ester ; fura-2 pentakis(acetoxymethyl) ester ; fura2/am *1set = 10x100ug** ; fura?-am ; fura-2/am, for fluorescence ; fura 2/am ; acetoxymethyl ester of fura 2 ; fura 2/am in solution ; fura 2-am yellow powder

Description

FURA 2/AM is the cell-permeable ester form of FURA 2, which is a fluorescent chelator (Kd = 224 nM) selective for Ca²⁺ over other ions and offers 30 times greater fluorescence intensity than QUIN 2. FURA 2/AM is rapidly metabolized in the cell by cytoplasmic esterases; yielding the active dye FURA 2. FURA 2/AM can be used as a probe to determine calcium concentrations in many cellular systems, including: cardiac myocytes, vascular smooth muscle cells, and medullary collecting tubules. Spectral properties in the presence of low calcium concentrations (excitation max = 362 nm, emission max = 512 nm) differ from those during high calcium conditions (excitation max = 335 nm, emission max = 505 nm).