PARP inhibitor III (DPQ) is a highly potent and selective inhibitor of PARP (Poly ADP-ribose polymerase) (IC50 = 40 nM). The PARP family is comprised of 17 nuclear enzymes involved in a myriad of cellular functions such as apoptosis, DNA repair, telometric maintenance and post-translational modification. DNA damage from oxidative and nitrosative stress can activate PARP, which catalyzes teh attachment of ADP ribose units from NAD to nuclear proteins. PARP also plays an important role in activating inflammatory genes, which can serve as a useful research topic for various cardiovascular and inflammatory diseases. Research shows that rapid activation of the enzyme depletes intracellular concentrations of NAD, thus slowing the rate of glycolysis, electron transport and subsequently ATP formation, resulting in cellular dysfunction and death. PARP Inhibitor III, DPQ is an inhibitor of PARP-1 and PARP-2.