DDMS | CAS 206052-03-1 | Chemical-Suppliers

Element: ddms

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C-S » Chemicals » ddms-PX73779

Identification

DDMS

CAS:

206052-03-1

EINECS:

Molecular Formula:

C₁₃H₂₃Br₂NO₃S

MDL:

MFCD08062215

SMILES:

CS(=O)(=O)NC(=O)CCCCCCCCCC=C(Br)Br

Synonym:

dibromo-dodecenyl-methylsulfimide ; 11-dodecenamide, 12,12-dibromo-n-(methylsulfonyl)- ; ddms ; 12,12-dibromo-n-(methylsulfonyl)-11-dodecenamide

Description

DDMS is a mechanism-based, irreversible inhibitor that has about 10-fold selectivity for the CYP4A11 (CYP450 4A2) enzyme which predominantly synthesizes 20-HETE in the mammalian kidney. DDMS administration in whole anesthetized rats (10 mg/kg) largely ablates the hypotension and vasodilation induced by nitric oxide donors such as NONOates. Biosynthesis of 20-HETE from arachidonic acid by the CYP4A11 (cytochrome P450 4A) isoforms is an important component of vascular homeostasis, especially in renal circulation.

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Santa Cruz Biotechnology, Inc.

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Prices & Availability

Data is processed

Properties for DDMS

Molecular Weight:

433.2 g·mol−1

Solubility:

Soluble in water (0.5 mg/ml at 25.0° C), ethanol (~20 mg/ml), DMSO (~20 mg/ml), DMF (~20 mg/ml), and 1: 10 solution of DMF: PBS (pH 7.2) (0.5 mg/ml).

Safety & Transport Information

coming up soon

Alternative Distributors of [DDMS]

Producers or manufacturers change the product range from time to time. Currently there are no other manufacturers known.

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Mol File:

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MSDS:

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