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Clioquinol

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Formula: C9H5ClINO
CAS: 130-26-7
search Element: clioquinol
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Identification

Structural Formula
Clioquinol
CAS:
130-26-7
EINECS:
204-984-4
Molecular Formula:
C9H5ClINO
MDL:
MFCD00006787
SMILES:
C1=CC2=C(C(=C(C=C2Cl)I)O)N=C1
Synonym:
bactol ; rometin ; nioform ; corque ; emaform ; amoenol ; amebil ; oralcer ; hysone ; cortin


Description

Clioquinol is a member of the hydroxyquinoline family which inhibits certain enzymes related to DNA replication. Clioquinol is a metal chelating ligand which displays protective effects in various neurodegenerative states as well as being a component in antifungal and antiprotozoal agents. It has been shown to modulate amyloid beta-peptide accumulation via upregulation of metalloprotease activity. When co-administered with vitamin B12, Clioquinol rescues lead-induced impairments of synaptic plasticity in an animal models. In recent animal studies Clioquinol has shown to reverse the progression of Parkinson's, Alzheimer's, and Huntington's diseases. Clioquinol has been observed to induce apoptosis in human cancer cell lines by generating free zinc in lysosomes.


Suppliers

Aozeal Certified Standards (AOCS), Inc.
C0067.00
+
H&Z Industry Co.,Ltd
HIC200800
+
Shandong SanYoung Industry Co., Ltd
SSI3501400
+
Caesar & Loretz GmbH
CL200600
+
Xiamen Equation Chemical Co.,Ltd
XECC3201600
+
CSNpharm, Inc.
CSN10054
Hangzhou Lingrui Chemical Co., Ltd.
HLC3501400
+
Sigma-Aldrich International GmbH
SI320960
+
Finetech Industry Limited
FIL2501000
+
Simagchem Corporation
SC210630
+
Xingrui Industry Co., Limited
XIL2901160
+
Leap Chem Co., Ltd
LC180540
+
Santa Cruz Biotechnology, Inc.
201066
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IODOCHLOROHYDROXYQUINOLINE
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Angene International Limited
AGN-PC-0JK6CO
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Manchester Organics Limited
Z35558
5-Chloro-8-hydroxy-7-iodoquinoline
TCI Chemicals (India) Pvt. Ltd.
C0187
7-Iodo-5-chloro-8-hydroxyquinoline
IBIS Chemie International
ICI255010200
5-Chloro-8-hydroxy-7-iodoquinoline, 98%
Alfa (A Johnson Matthey Company)
A374411232
Iodochlorohydroxyquinoline / Clioquinol
Exim Corporation
EC12483744

Prices & Availability




Data is processed


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Properties for Clioquinol

Molecular Weight:
305.5 g·mol−1
Density:
~2.0 g/cm3 (Predicted)
Melting point:
175-183 °C
Boiling point:
~350.4° C at 760 mmHg (Predicted)
Solubility:
Soluble in DMSO (>25 mg/ml), boiling alcohol ((1:43)), methanol, and chloroform ((1:120)).
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Hazard Statements

GHS07

GHS03
Harmful
  • Acute toxicity (oral, dermal, inhalation), category 4
  • Skin irritation, categories 2, 3
  • Eye irritation, category 2A
  • Skin sensitization, category 1
  • Specific target organ toxicity following single exposure, category 3
    - Respiratory tract irritation
    - Narcotic effects
    • Not used
  • with the "skull and crossbones" pictogram
  • for skin or eye irritation if:
  • the "corrosion" pictogram also appears
  • the "health hazard" pictogram is used to indicate respiratory sensitization
GHS08

GHS08
Health hazard
  • Respiratory sensitization, category 1
  • Germ cell mutagenicity, categories 1A, 1B, 2
  • Carcinogenicity, categories 1A, 1B, 2
  • Reproductive toxicity, categories 1A, 1B, 2
  • Specific target organ toxicity following single exposure, categories 1, 2
  • Specific target organ toxicity following repeated exposure, categories 1, 2
  • Aspiration hazard, categories 1, 2

Safety & Transport Information

Risk Codes:
R25 - Toxic if swallowed
Safety Codes:
S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection
S45 - In case of accident or if you feel unwell seek medical advice immediately (show the label where possible)
Hazard Classes:
6.1(b)
Hazard Symbols:
T
Hazard symbol T
Storage temperature :
2-8°C
RID/ADR certification :
UN 2811 6.1 / PG 3
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Alternative Distributors of [Clioquinol]

Producers or manufacturers change the product range from time to time. The following companies
have appeared as suppliers in the past / currently not verified

Spectrum Chemical Mfg. Corp. | CCS. CHEM. Co., Ltd. | 3B Scientific Corporation | Nantong Chem-Tech. (Group) Co., Ltd. | G. Amphray Laboratories | Chengdu Qiaofeng Technological Development Co., Ltd. | Shanghai AOKChem Group Limited | Jinan Great Chemical Co., Ltd. | Cfm Oskar Tropitzsch GmbH | Watson International Ltd | Jinan Haohua Industry Co., Ltd. | Xiamen Hisunny Chemical Co., Ltd. | Haihang Industry Co., Ltd. | Clearsynth Canada INC.

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MSDS:
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