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Caffeic acid phenethyl ester

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Formula: C17H16O4
CAS: 104594-70-9

Identification

Structural Formula
Caffeic acid phenethyl ester
CAS:
104594-70-9
EINECS:
Molecular Formula:
C17H16O4
MDL:
MFCD00866470
SMILES:
C1=CC=C(C=C1)CCOC(=O)/C=C/C2=CC(=C(C=C2)O)O
Synonym:
phenethyl caffeate ; cape,phenethylcaffeate ; caffeic acid phenethyl ; propolis powder extract ; phenylethy caffeate ; beta-phenylethylcaffeate ; phenethyl caffeate (cape) ; phenylethyl caffeate ; caffeicacidphenyletherester ; kaffeesurephenylethylester


Description

CAPE (Caffeic acid phenethyl ester) is a constituent of the propolis of honeybee hives and has been shown to contain inhibitory effects on induced papilloma promotion in mice. Studies have shown that CAPE acts as an anti-proliferative agent in over-productive cell growth. It is also shown that CAPE can cause DNA fragmentation and apoptosis which can have toxic results towards cloned rat embryo fibroblast (CREF) cells. In addition, CREF cells depleted of cellular glutathione (GSH) seemed to be more sensitive to CAPE-induced cell death.

CAPE has been reported to have anti-carcinogenic, anti-inflammatory, and immunomodulatory properties. CAPE also inhibits HIV-1 integrase. The anti-inflammatory characteristics have been thought to be due to suppression of the lipoxygenase pathway of arachidonic acid metabolism by CAPE. Studies have also demonstrated CAPE to be a specific and potent inhibitor of activation of nuclear transcription factor NF kappa B, which is a protein complex that controls the transcription of DNA. CAPE (Caffeic Acid Phenethylester) is an inhibitor of ODC and Tyrosine Kinase.


Suppliers

Chemlyte Solutions
CS20166048
Ambeed, Inc.
A158279
ReseaChem
RCG-184
Autech Industry Co.,Limited
AIC302412096
Conscientia Industrial Co., Ltd (Zhejiang Conscientia Pharmaceutical)
CI772830912
Indofine Chemical Co, Inc.
Bio-586
Evonik ( formerly Wilshire Technologies, Inc. )
E537621504
Sancai Industry Co.,Ltd.
SIC268810752
CSNpharm, Inc.
CSN10538
Hangzhou Lingrui Chemical Co., Ltd.
HLC392015680
Carbone Scientific Co., Ltd.
CS31369408
Zehao Industry Co., Ltd.
ZI26888064
Santa Cruz Biotechnology, Inc.
200800
Chemos GmbH & Co. KG
CC22406720
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Angene International Limited
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Prices & Availability




Data is processed


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Properties for Caffeic acid phenethyl ester

Molecular Weight:
284.31 g·mol−1
Density:
~1.3 g/cm3 (Predicted)
Melting point:
173.38° C
Boiling point:
~498.6° C at 760 mmHg (Predicted)
Solubility:
Soluble in DMSO (10 mg/ml), ethanol (100 mM), ethyl acetate (50 mg/ml), methanol, acetone, and acetonitrile. Insoluble in water.
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Safety & Transport Information

Risk Codes:
R36/37/38 - Irritating to eyes, respiratory system and skin
Safety Codes:
S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
S36 - Wear suitable protective clothing
Hazard Symbols:
Xi
Hazard symbol Xi
Storage temperature :
Store at 0 °C
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Alternative Distributors of [Caffeic acid phenethyl ester]

Producers or manufacturers change the product range from time to time. The following companies
have appeared as suppliers in the past / currently not verified

Chem-Impex International, Inc. | Carl Roth GmbH + Co KG | Yancheng Langde Chemical & Pharmaceutical Co., Ltd. | Suzhou Rovathin Pharmatech Co., Ltd | Jinan Haohua Industry Co., Ltd.

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