Bortezomib | CAS 179324-69-7 | Chemical-Suppliers

Element: bortezomib

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C-S » Chemicals » bortezomib-PX78409

Identification

Bortezomib

CAS:

179324-69-7

EINECS:

Molecular Formula:

C₁₉H₂₅BN₄O₄

MDL:

MFCD09056737

SMILES:

CC(C)C[C@H](NC(=O)[C@@H](CC1=CC=CC=C1)NC(=O)C2=NC=CN=C2)B(O)O

Synonym:

mlm341 ; bortezomib-d8 ; radiciol ; bortezmib ; bortezomib base ; bortezomib r ; dpba ; mg-341 ps-341 ; bortezomib ; velcade

Description

Bortezomib is a selective and robust 26S proteasome inhibitor, that is a boronic acid dipeptide derivative. Human pancreatic cancer cell studies demonstrate Bortezomib to inhibit the PKR-like endoplasmic reticulum (ER) kinase and enhance ER stress, leading to apoptosis. Studies suggest that Bortezomib affects the gene expression of WT1, and blocks the function of human plasmacytoid DCs through the inhibition of intracellular trafficking of Toll-like receptors and modification of the ER homeostasis. Additionally, Bortezomib has been reported to inhibit necrosis and cell proliferation, and downregulate metastatic gene expression. Bortezomib is an inhibitor of 20S Proteasome.

Suppliers

FUDI Chemical Co. Ltd.

FCC220880

Conscientia Industrial Co., Ltd (Zhejiang Conscientia Pharmaceutical)

CI6902760

Shandong Ench Chemical Co.,Ltd

SECC3001500

Aozeal Certified Standards (AOCS), Inc.

B0021.00

Ambeed, Inc.

A385479

Aea.ltd

A70140

Shandong SanYoung Industry Co., Ltd

SSI3501400

Nantong Xindao Biotech Ltd

NXB2601040

H&Z Industry Co.,Ltd

HIC200800

Alpha Biopharmaceuticals Co., Ltd.

AB3401020

Beijing Pure Chem. Co., Ltd.

BPC2801120

Hangzhou Verychem Science & Technology Co., Ltd.

HVST4802400

Xiamen Equation Chemical Co.,Ltd

XECC3201600

Aecochem Corp.

AC140420

CSNpharm, Inc.

CSN10115

Wanko Chemical Co., Ltd.

WC240720

scienTEST - bioKEMIX GmbH

S-B2501000

Finetech Industry Limited

FIL2501000

Pharmacore Co., Limited

PL230690

Hefei Hirisun Pharmatech Co., Ltd

HR120032

Xingrui Industry Co., Limited

XIL2901160

Capot Chemical Co., Ltd.

17777

BOC Sciences

BS120360

Amadis Chemical Company Limited

ACCL3101550

Leap Chem Co., Ltd

LC180540

Santa Cruz Biotechnology, Inc.

217785

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CAS equal suppliers

PS-341

Aea.ltd

A4284

((R)-3-Methyl-1-((S)-3-phenyl-2-(pyrazine-2-carboxamido)propanamido)butyl)boronic acid

BLD Pharmatech Ltd

BP2167265016

Bortezomib; MG-341; PS-341; (R)-3-methyl-1-((S)-3-phenyl-2-(pyrazine-5-carboxamido)propanamido)butylboronic acid

3B (Wuhan) Scientific Corporation

359136177408

Bortezomib (Velcade, [(1R)-3-Methyl-1-[[(2S)-1-oxo-3-phenyl-2-[(pyrazinylcarbonyl)amino]propyl]amino]butyl]-boronic Acid)

United States Biological

B2572

Prices & Availability

Data is processed

Properties for Bortezomib

Molecular Weight:

384.24 g·mol−1

Density:

1.214

Melting point:

122-124 °C

Boiling point:

684.30° C (Predicted)

Solubility:

Soluble in chloroform, DMSO (200 mg/ml), ethanol (200 mg/ml), and methanol. Partly miscible in water.Maximum solubility in plain water is estimated to be about 5-10 µM. Buffers, serum, or other additives may increase or decrease the aqueous solubility.

Hazard Statements

GHS06
Toxic

Acute toxicity (oral, dermal, inhalation), categories 1, 2, 3

GHS08
Health hazard

Respiratory sensitization, category 1
Germ cell mutagenicity, categories 1A, 1B, 2
Carcinogenicity, categories 1A, 1B, 2
Reproductive toxicity, categories 1A, 1B, 2
Specific target organ toxicity following single exposure, categories 1, 2
Specific target organ toxicity following repeated exposure, categories 1, 2
Aspiration hazard, categories 1, 2

Safety & Transport Information

Storage temperature :

Hygroscopic, -20 °C Freezer, Under Inert Atmosphere

Alternative Distributors of [Bortezomib]

Producers or manufacturers change the product range from time to time. The following companies
have appeared as suppliers in the past / currently not verified