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BEZ235

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Formula: C30H23N5O
CAS: 915019-65-7
search Element: bez235
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Identification

Structural Formula
BEZ235
CAS:
915019-65-7
EINECS:
Molecular Formula:
C30H23N5O
MDL:
MFCD10565944
SMILES:
CC(C)(C#N)C1=CC=C(C=C1)N2C3=C4C=C(C=CC4=NC=C3N(C2=O)C)C5=CC6=CC=CC=C6N=C5
Synonym:
dactolisib ; nvp-bez235(bez235) ; nvp-bez 235 ; bez-235 (dactolisib) ; 2-methyl-2-[3-methyl-2-oxo-8-(3-quinolinyl)-1-imidazo[4,5-c]quinolinyl]propanenitrile ; bez235, >=98% ; bez-235 ; bez235 (nvp-bez235, dactolisib) ; bez235 0.6g ; bez235 (nvp-bez235)


Description

BEZ235 is a PI 3-kinase (PI3K) tyrosine kinase inhibitor and shows dual PI3K/mTOR inhibition (IC50 = 4, 5, 7 and 75 nM for PI 3-Kα, -γ, -δ, and -β, respectively). BEZ235 showed high target specificity and demonstrated antiproliferative activity against tumor cell lines in animal models of cancer. BEZ235 is an mTOR Complex 1 and mTOR Complex 2 catalytic inhibitor. BEZ235 also inhibits ATR (IC50 = 21nM).


Suppliers

Ambeed, Inc.
A224243
+
Aea.ltd
A4284
+
CSNpharm, Inc.
CSN12260
Santa Cruz Biotechnology, Inc.
364429
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CAS equal suppliers

Dactolisib
AK Scientific, Inc.
AS190570
NVP-BEZ 235
Dayang Chem (Hangzhou) Co.,Ltd.
DC3411364
NVP-BEZ 235
Simagchem Corporation
SC231693
NVP-BEZ 235
Chemieliva Pharmaceutical Co., Ltd.
CP3851155
NVP-BEZ 235
Leap Chem Co., Ltd
LC198594
NVP-BEZ 235
Capot Chemical Co., Ltd.
16657
NVP-BEZ 235
Finetech Industry Limited
FIL2751100
NVP-BEZ 235
Gihi Chemicals Co., Limited
GCL2971188
NVP-BEZ 235
Aea.ltd
A77154
BEZ235 - NVP-BEZ235
Salsbury Chemicals, Inc.
SC13684104
2-methyl-2-(4-(3-methyl-2-oxo-8-(quinolin-3-yl)-2,3-dihydro-1H-imidazo[4,5-c]quinolin-1-yl)phenyl)propanenitrile
Hefei Hirisun Pharmatech Co., Ltd
HR013029
2-methyl-2-(4-(3-methyl-2-oxo-8-(quinolin-3-yl)-2,3-dihydro-1H-imidazo[4,5-c]quinolin-1-yl)phenyl)propanenitrile
3B (Wuhan) Scientific Corporation
359136177408

Prices & Availability




Data is processed


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Properties for BEZ235

Molecular Weight:
469.54 g·mol−1
Density:
1.299
Melting point:
288-289 °C
Boiling point:
701.03 °C at 760 mmHg (Predicted)
Solubility:
Soluble in chloroform (1 mg/ml), 1-methyl-2-pyrrolidnone (2 mg/mL at 75 °C), DMSO (1.33 mg/mL), and DMF (10 mg/mL at 75 °C).
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Safety & Transport Information

Storage temperature :
Refrigerator
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Alternative Distributors of [BEZ235]

Producers or manufacturers change the product range from time to time. The following companies
have appeared as suppliers in the past / currently not verified

ShangHai Biochempartner Co., Ltd.

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Downloads

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MSDS:
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