(RS)-APICA

(RS)-APICA is a rigidified analog of MPPG; a selective group II metabotropic glutamate receptor antagonist (IC₅₀ = 30 µM) with no significant effect on group I and III mGlu receptors at concentrations up to 1 mM. (RS)-APICA increases extracellular glutamate concentrations and possesses an unusual inverse agonist-like action.