Chemical-Suppliers Chemical-Suppliers

API-1

×
Formula: C13H15N5O6
CAS: 36707-00-3
search Element:
Page Content Identification Properties Suppliers Prices & Availability Get Quick Quote ☰

Identification

Structural Formula
API-1
CAS:
36707-00-3
EINECS:
Molecular Formula:
C13H15N5O6
MDL:
MFCD18086904
SMILES:
C1=C(C(=O)C2=C(N1C3C(C(C(O3)CO)O)O)N=CN=C2N)C(=O)N
Synonym:
5-amino-10-[3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-7-oxo-2,4,10-triazabicyclo[4.4.0]deca-1,3,5,8-tetraene-8-carboxamide ; nsc 177223 ; 4-amino-5,6,7,8-tetrahydro-5-oxo-8-(β-d-ribofuranosyl)pyrido[2,3-d]pyrimidine-6-carboxamide ; 4-amino-5,8-dihydro-5-oxo-8-β-d-ribofuranosyl-pyrido[2,3-d]pyrimidine-6-carboxamide ; api-1


Description

API-1 is a PKB inhibitor. The compound acts by halting Akt membrane translocation through binding the pleckstrin homology domain of Akt. API-1 also inhibits EGF-induced kinase activity of Akt1, AKT2 and AKT3. Activity results in cell growth arrest and apoptosis in human cancer cells with constitutively active Akt. Both in vivo and in vitro antitumor activity has been observed along with cell arrest and apoptosis in cancer cells with constitutive Akt activity.


Suppliers

Amadis Chemical Company Limited
ACCL155775
+
Santa Cruz Biotechnology, Inc.
361106
Get Quick Quote

CAS equal suppliers

NSC177223
ShangHai Biochempartner Co., Ltd.
BCP24669
NSC177223
Excenen Pharmatech Co., Ltd.
EN-3959
NSC 177223
Aea.ltd
A70140

Prices & Availability




Data is processed


x

Properties for API-1

Molecular Weight:
337.2881 g·mol−1
Density:
1.792 g/cm3
Boiling point:
795.8°C at 760 mmHg
Flash point:
435.1°C
Solubility:
Soluble in DMSO (100 mM).
x

Safety & Transport Information

Storage temperature :
Store at RT
x

Alternative Distributors of [API-1]

Producers or manufacturers change the product range from time to time. Currently there are no other manufacturers known.
x

Downloads

Mol File:
-/-
MSDS:
-/-

















▲
▲