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17-AAG

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Formula: C31H43N3O8
CAS: 75747-14-7
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Identification

Structural Formula
17-AAG
CAS:
75747-14-7
EINECS:
Molecular Formula:
C31H43N3O8
MDL:
MFCD04973892
SMILES:
C[C@H]1C[C@@H]([C@@H]([C@H](/C=C(/[C@@H]([C@H](/C=CC=C(C(=O)NC2=CC(=O)C(=C(C1)C2=O)NCC=C)/C)OC)OC(=O)N)C)C)O)OC
Synonym:
telatinib ; 17-ag ; 17-aag,17aag ; nsc-330507 ; 17-aag ; cp 127374 ; 17-agg ; tanespimycin ; gld-36 ; kos 953


Description

17-AAG is a less toxic and more stable analog of geldanamycin. It acts an Hsp90 inhibitor that displays a 100-fold higher affinity for Hsp90 derived from tumor cells compared to Hsp90 from normal cells. 17-AAG inhibits Akt1 (Akt) activation and expression in tumors and synergizes with a number of anti tumor agents such as taxol2, cisplatin3, and UCN-014. 17-AAG causes the inactivation, destabilization and eventual degradation of HIF-1α5. 17-AAG is an inhibitor of K-Ras and N-Ras.


Suppliers

Aea.ltd
A4284
+
Ambeed, Inc.
A220462
+
CSNpharm, Inc.
CSN17209
Iris Biotech GmbH
LS-1000.0001
+
Amadis Chemical Company Limited
ACCL186930
+
Santa Cruz Biotechnology, Inc.
200641
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Gihi Chemicals Co., Limited
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Santa Cruz Biotechnology, Inc.
sc-213619
17-(Allylamino)-17-demethoxygeldanamycin
Iris Biotech GmbH
LS-1000
17-(Allylamino)-17-demethoxygeldanamycin, 99%
Alfa (A Johnson Matthey Company)
A576017280
17-Allylamino-17-demethoxygeldanamycin (17-AAG)
Molekula
83001326
17-Allylamino-17-dimethoxygeldanamycin (17-AAG)
Haihang Industry Co., Ltd.
HI366610998
(4E,6Z,8S,9S,10E,12S,13R,14S,16R)-19-(allylamino)-13-hydroxy-8,14-dimethoxy-4,10,12,16-tetramethyl-3,20,22-trioxo-2-azabicyclo[16.3.1]docosa-1(21),4,6,10,18-pentaen-9-yl carbamate
BLD Pharmatech Ltd
BP70884212652

Prices & Availability




Data is processed


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Properties for 17-AAG

Molecular Weight:
585.69 g·mol−1
Density:
1.21
Melting point:
201-203 °C
Boiling point:
797.82° C at 760 mmHg
Solubility:
DMSO: soluble
x

Safety & Transport Information

Risk Codes:
R36/37/38 - Irritating to eyes, respiratory system and skin
Safety Codes:
S22 - Do not breathe dust
S24/25 - Avoid contact with skin and eyes
S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
S36 - Wear suitable protective clothing
Hazard Symbols:
Xi
Hazard symbol Xi
Storage temperature :
-20°C
x

Alternative Distributors of [17-AAG]

Producers or manufacturers change the product range from time to time. The following companies
have appeared as suppliers in the past / currently not verified

Cfm Oskar Tropitzsch GmbH

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Downloads

Mol File:
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MSDS:
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