SE 175

SE 175 is an organic nitrate compound of the same general class as nitroglycerin. These nitrate compounds can act as NO-donors under physiological conditions following reductive transformation of the nitrate group to nitric oxide. The nitroxyacylated thiosalicylates, such as SE 175, were developed in an effort to facilitate this reductive process and accelerate the release of NO. SE 175 is stable in buffer or saline solution. In studies with rats, it has been shown to stimulate endothelial soluble guanylate cyclase (sGC) and induce aortic vasorelaxation (EC₅₀ = 20 µM). The potency of SE 175 lies between that of nitroglycerine and isosorbide dinitrate.