SL-327 | CAS 305350-87-2 | Chemical-Suppliers

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C-S » Chemicals » -PX77771

Identification

SL-327

CAS:

305350-87-2

EINECS:

Molecular Formula:

C₁₆H₁₂ F₃ N₃ S

MDL:

MFCD06411432

SMILES:

C1=CC=C(C(=C1)/C(=C(N)/SC2=CC=C(C=C2)N)/C#N)C(F)(F)F

Synonym:

α-[amino-(4-aminophenylthio)methylene)-2-(trifluoromethyl)phenylacetonitrile ; sl 327 alpha-[amino[(4-aminophenyl)thio]methylene]-2-(trifluoromethyl)benzeneacetonitrile ; alpha-[amino[(4-aminophenyl)thio]methylene]-2-(trifluoromethyl)benzeneacetonitrile ; (2z)-3-amino-3-[(4-aminophenyl)sulfanyl]-2-[2-(trifluoromethyl)phenyl]prop-2-enenitrile ; a-[amino[(4-aminophenyl)thio]methylene]-2-(trifluoromethyl)benzeneacetonitrile ; (z)-3-amino-3-(4-aminophenylthio)-2-(2-(trifluoromethyl)phenyl)acrylonitrile ; sl 327 ; benzeneacetonitrile, a-[amino[(4-aminophenyl)thio]methylene]-2-(trifluoromethyl)- ; sl327 ; α-[amino[(4-aminophenyl)thio]methylene]-2-(trifluoromethyl)benzeneacetonitrile ; z-and e-alpha-(amino-((4-aminophenyl)thio)methylene)-2-(trifluoromethyl)benzeneacetonitrile ; alpha-[amino-(4-aminophenylthio)methylene)-2-(trifluoromethyl)phenylacetonitrile

Description

SL-327 is a cell-permeable vinylogous cyanamide that acts as a selective inhibitor of MEK-1 and MEK-2 (IC₅₀ = 0.18 and 0.22 μM respectively). This compound has been shown to block hippocampal LTP via inhibition of the MAPK/ERK cascade, which prevents CREB and Elk-1 phosphorylation, and LTP-dependent gene induction, resulting in rapidly decaying LTP, while being uncompetitive with respect to ATP. SL-327 has also been shown to inhibit ERK1, MEK-3/p38, MEK-4, JNK, and PKC activities when used at higher concentrations.

Suppliers

Santa Cruz Biotechnology, Inc.

200685

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(Z)-3-Amino-3-(4-aminophenylthio)-2-(2-(trifluoromethyl)phenyl)acrylonitrile

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alpha-[Amino[(4-aminophenyl)thio]methylene]-2-(trifluoromethyl)benzeneacetonitrile

Haihang Industry Co., Ltd.

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Prices & Availability

Data is processed

Properties for SL-327

Molecular Weight:

335.35 g·mol−1

Density:

1.4 g/cm3

Melting point:

127-128.2 °C

Boiling point:

512.6°C at 760 mmHg

Flash point:

263.8°C

Solubility:

DMSO: 32 mg/mL

Safety & Transport Information

Storage temperature :

2-8°C

Alternative Distributors of [SL-327]

Producers or manufacturers change the product range from time to time. The following companies
have appeared as suppliers in the past / currently not verified

BOC Sciences | Abcam Biochemicals plc (formaly Ascent Scientific Ltd.) | Shanghai Witofly Chemical Co., Ltd.

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