AG 126 | CAS 118409-62-4 | Chemical-Suppliers

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Identification

AG 126

CAS:

118409-62-4

EINECS:

Molecular Formula:

C₁₀H₅N₃O₃

MDL:

MFCD00236448

SMILES:

C1=CC(=C(C=C1C=C(C#N)C#N)O)[N+](=O)[O-]

Synonym:

ag127 ; tyrphostin a10 ; ag 126 ; rarechem al bx 0673 ; tyrphostin 126 ; tyrphostin ag 126 ; [3-hydroxy-4-nitrobenzylidene]malononitrile ; alpha-cyano-(3-hydroxy-4-nitro)cinnamonitrile

Description

AG 126 selectively inhibits the phosphorylation of ERK1 and ERK2 at 25-50 μM. It also acts as a cell-permeable inhibitor of lipopolysaccharide (LPS)-induced synthesis of tumor necrosis factor-α (TNF α) and nitric oxide in murine peritoneal macrophages. AG 126 blocks LPS-induced tyrosine phosphorylation of a p42MAPK/ERK2 protein substrate, as well as glucocorticoid-induced COX-2 activity in cells (IC₅₀ = 15.38 μM).

Suppliers

Amadis Chemical Company Limited

ACCL186930

Santa Cruz Biotechnology, Inc.

3528

Dayang Chem (Hangzhou) Co.,Ltd.

DC186744

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CAS equal suppliers

AG-126

Ambeed, Inc.

A860936

AG-126

CSNpharm, Inc.

CSN21221

Prices & Availability

Data is processed

Properties for AG 126

Molecular Weight:

215.16 g·mol−1

Density:

1.50 g/cm³ (Predicted)

Melting point:

181-182° C

Boiling point:

381.88° C at 760 mmHg (Predicted)

Solubility:

Soluble in DMSO (25 mg/ml), ethanol (5 mg/ml), DMF (~10 mg/ml), DMSO:PBS (1:1 pH 7.2) (0.5 mg/ml), and water (partly miscible).

Safety & Transport Information

Risk Codes:

R23/24/25 - Toxic by inhalation, in contact with skin and if swallowed

Safety Codes:

S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
S36 - Wear suitable protective clothing
S45 - In case of accident or if you feel unwell seek medical advice immediately (show the label where possible)

Hazard Symbols:

Storage temperature :

-20°C

Alternative Distributors of [AG 126]

Producers or manufacturers change the product range from time to time. Currently there are no other manufacturers known.

Downloads

Mol File:

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MSDS:

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