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AG 538

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Formula: C16H11 N O5
CAS: 133550-18-2
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Identification

Structural Formula
AG 538
CAS:
133550-18-2
EINECS:
Molecular Formula:
C16H11 N O5
MDL:
MFCD03453581
SMILES:
C1=CC(=C(C=C1C=C(C#N)C(=O)C2=CC(=C(C=C2)O)O)O)O
Synonym:
ag 538, (αe)-α-[(3,4-dihydroxyphenyl)methylene]-3,4-dihydroxy-β-oxo-benzenepropanenitrile ; ag 538 ; (αe)-α-[(3,4-dihydroxyphenyl)methylene]-3,4-dihydroxy-β-oxo-benzenepropanenitrile ; benzenepropanenitrile, a-[(3,4-dihydroxyphenyl)methylene]-3,4-dihydroxy-b-oxo-, (ae)- ; benzenepropanenitrile,a-[(3,4-dihydroxyphenyl)methylene]-3,4-dihydroxy-b-oxo-, (e)-


Description

AG 538 is a potent, competitive inhibitor of IGF-IR (IGF-1 receptor kinase, IC50 = 400 nM). Reaction is competitive with respect to IGF-1R substrate. Also inhibits the phosphorylation of PTK substrate poly(Glu,Tyr) by IGF-1R, IR, EGF-R, and Src (IC50 = 60 nM, 113 nM, 370 nM, and 2.4 μM, respectively). Inhibits the phosphorylation of PKB at a much higher concentration (IC50 = 76 μM).


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Santa Cruz Biotechnology, Inc.
203807
Dayang Chem (Hangzhou) Co.,Ltd.
DC186744
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Properties for AG 538

Molecular Weight:
297.265 g·mol−1
Density:
1.54 g/cm3 (Predicted)
Boiling point:
637.48° C at 760 mmHg (Predicted)
Solubility:
Soluble in DMSO (5 mg/ml).
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Safety & Transport Information

Safety Codes:
S22 - Do not breathe dust
S24/25 - Avoid contact with skin and eyes
Storage temperature :
-20°C
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Alternative Distributors of [AG 538]

Producers or manufacturers change the product range from time to time. Currently there are no other manufacturers known.
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