AL 8810 | CAS 246246-19-5 | Chemical-Suppliers

Element: 8810

Page Content Identification Properties Suppliers Prices & Availability Get Quick Quote ☰

Identification Properties Suppliers Prices & Availability Get Quick Quote

C-S » Chemicals » -PX63307

Identification

AL 8810

CAS:

246246-19-5

EINECS:

Molecular Formula:

C₂₄H₃₁O₄F

MDL:

MFCD04039992

SMILES:

C1[C@@H]([C@@H]([C@H]([C@H]1F)/C=C/[C@@H](C2CC3=CC=CC=C3C2)O)C/C=CCCCC(=O)O)O

Synonym:

(5z,13e)-(9s,11s,15r)-9,15,dihydroxy-11-fluoro-15-(2-indanyl)-16,17,18,19,20,pentanor-5,13-prostadienoic acid ; [1r-[1α(z),2β(1e,3s*),3β,5α]]-7-[3-fluoro-5-hydroxy-2-[3-hydroxy-4-[2-(2,3-dihydro-1h-indenyl)]-1-butenyl]cyclolpentyl]-5-heptenoic acid, (5z, 13e)-(9s,11s,15r)-9,15,dihydroxy-11-fluoro-15-(2-indanyl)-16,17,18,19,20,pentanor-5,13-prostadienoic acid ; (5z, 13e)-(9s,11s,15r)-9,15,dihydroxy-11-fluoro-15-(2-indanyl)-16,17,18,19,20,pentanor-5,13-prostadienoic acid ; [1r-[1α(z),2β(1e,3s*),3β,5α]]-7-[3-fluoro-5-hydroxy-2-[3-hydroxy-4-[2-(2,3-dihydro-1h-indenyl)]-1-butenyl]cyclolpentyl]-5-heptenoic acid ; al 8810 ; [1r-[1alpha(z),2beta(1e,3s*),3beta,5alpha]]-7-[3-fluoro-5-hydroxy-2-[3-hydroxy-4-[2-(2,3-dihydro-1h-indenyl)]-1-butenyl]cyclolpentyl]-5-heptenoic acid ; 9alpha,15r-dihydroxy-11beta-fluoro-15-(2,3-dihydro-1h-inden-2-yl)-16,17,18, 19,20-pentanor-prosta-5z,13e-dien-1-oic acid

Description

AL 8810 is an 11β-fluoro analog of PGF2α which acts as a potent and selective antagonist at the PGF2αR (FP receptor). AL 8810 has weak intrinsic agonist activity on FP receptor preparations in the 200-300 nM range, yet it fully antagonizes the activity of the potent FP receptor agonist fluprostenol at this concentration, with EC50 values of approximately 430 nM. AL 8810 fully antagonized the bimatoprost-induced calcium mobilization in Swiss 3T3 fibroblasts at 100 μM, indicating that bimatoprost acts as an FP agonist in this preparation. The Ki for the inhibition of several potent agonists at the cloned human ciliary body FP receptor is in the range of 1-2 μM.

Suppliers

Santa Cruz Biotechnology, Inc.

205204

Dayang Chem (Hangzhou) Co.,Ltd.

DC217868

Get Quick Quote

CAS equal suppliers

AL8810

ShangHai Biochempartner Co., Ltd.

BCP16368

Prices & Availability

Data is processed

Properties for AL 8810

Molecular Weight:

402.5 g·mol−1

Density:

~1.2 g/cm³ (Predicted)

Melting point:

232.63° C (Predicted)

Boiling point:

~594.6° C at 760 mmHg (Predicted)

Solubility:

DMSO: 10 mg/mL, soluble

Safety & Transport Information

Storage temperature :

2-8°C

Alternative Distributors of [AL 8810]

Producers or manufacturers change the product range from time to time. Currently there are no other manufacturers known.

Downloads

Mol File:

-/-

MSDS:

-/-